副教授
Tel：+86 15109241341
E-mail: changyc@mail.buct.edu.cn
研究方向：
1) 以氧化态二茂铁为还原响应性基团，构建了一系列刺激响应性多功能药物/siRNA 共运输体系，在细胞和活体实验中证明，这些体系可以减小化疗药物的副作用，并有望克服癌细胞的耐药性。
2) 基于电荷反转两亲分子和电荷反转柱芳烃，以细胞膜为作用靶点，初步建立了破膜抗癌新体系，实现了选择性破膜抗癌，为化疗药物的研发提供了新的思路。
3）基于超分子策略，构建安全高效，波长可调的超分子光引发剂。
2016.8 - 2019.8 清华大学，化学系 博士后
2012.9 - 2016.7 西北农林科技大学，化学与药学院 理学博士
2008.9 - 2012.7 西北农林科技大学，创新实验学院 理学学士
2019.9至今 北京化工大学 材料科学与工程学院 副教授
近年在Chem. Soc. Rev.; Angew. Chem. Int. Ed.; Adv. Funct. Mater.; Sci. Adv.等杂志发表论文十余篇。获选全国博士后创新人才支持计划，陕西省优秀博士论文等荣誉。
1. Chang Y, Jiao Y, Symons H, Xu J-F, Faul C, Zhang X. Molecular Engineering of Polymeric Supra-amphiphiles. Chemical Society Reviews , 2019, 48, 989-1003.
2. Chang Y, Yang K, Wei P, Huang S, Pei Y, Zhao W, Pei Z. Cationic Vesicles Based on Amphiphilic Pillar [5] arene Capped with Ferrocenium: A Redox-Responsive System for Drug/siRNA Co-Delivery. Angewandte Chemie International Edition , 2014, 53, 13126-13130. (ESI高被引论文)
3. Chang Y, Lv Y, Wei P, Zhang P, Pu L, Chen X, Yang K, Li X, Lu Y, Hou C, Pei Y, Zeng W, Pei Z. Multifunctional Glyco-Nanofibers: siRNA Induced Supermolecular Assembly for Codelivery In Vivo . Advanced Functional Material s, 2017, 27, 1703083.
4. Zeng L, Chang Y, Wu Y, Yang J, Xu J.-F, Zhang X. Charge-reversal surfactant antibiotic used in the displacement of reservoir oil to reduce the microbial corrosion. Science Advances , 2020, Accepted.
5. Tang B, Li W, Chang Y, Yuan B, Wu Y, Zhang M, Xu J.-F, Li J, Zhang X. A Supramolecular Radical Dimer: High-Efficiency NIR-II Photothermal Conversion and Therapy. Angewandte Chemie International Edition , 2019, 58, 15526-15531.
6. Chang Y, Chen J, Yang J, Lin T, Zeng L, Xu J-F, Hou J, Zhang X. Targeting Cell Membrane by Charge-Reversal Amphiphilic Pillar[5]arene for the Selective Killing of Cancer Cells. ACS Appl. Mater. Interfaces , 2019, 11, 38497-38502.
7. Chang Y, Huang Z, Jiao Y, Xu J-F, Zhang X. pH-Induced Charge-Reversal Amphiphile with Cancer Cell-Selective Membrane-Disrupting Activity. ACS Applied Materials & Interfaces, 2018, 10, 21191-21197.
8. Chang Y, Hou C, Ren J, Xin X, Pei Y, Lu Y, Cao S, Pei Z. Multifunctional Supramolecular Vesicles Based on the Complex of Ferrocenecarboxylic Acid Capped Pillar[5]arene and a Galactose Derivative for Targeted Drug Delivery. Chemical Communications , 2016, 52, 9578-9581.
9. Yang K, Chang Y, Wen J, Lu Y, Pei Y, Cao S, Wang F, Pei Z. Supramolecular Vesicles Based on Complex of Trp-modified Pillar[5]arene and Galactose Derivative for Synergistic and Targeted Drug Delivery. Chemistry of Materials , 2016, 28, 1990-1993.
10. Chang Y, Pei Z, Shuai Q. Two Luminescent Complexes Constructed from Different Metals with Pyridine-2, 4-dicarboxylic Acid (H2PDC). Journal of Coordination Chemistry , 2013, 66, 3137-3148.
11. Chang Y, Pei Z, Shuai Q. Bis(µ-3-nitrobenzene-1,2-dicarboxy-lato)- κ 4 O 1, O 2: O 1, O 1'; κ 4 O 1, O 1': O 1, O 2-bis[triaqua(6-carboxy-2-nitrobenzoato- κ 2 O 1, O 6) neodymium(III)] dehydrate. Acta Crystallographica Section E: Structure Reports Online , 2012, E68: m1379.
