Preparation and Dissolution of Solid Dispersions of Sanguis Draconis

XING Chang Min, WANG Xue Ming, CAO Kuan, LIU Hui Chao, LIU Yong * and LI Nan*

Abstract：Sanguis draconis is a precious traditional Chinese medicine, but it is not soluble in water, and it is difficult to use in type of injection. Sanguis draconis has a low bioavailability, because the coarse particles of draconis can be absorbed very little. In present research, solid dispersions of sanguis draconis were prepared using solvent method and melting methods with PEG-6000 and PVPK30 as carriers. The dissolubility in vitro was determined by UV method. Results showed that higher carrier ratio led to faster drug dissolution. The dissolubility of solid dispersions with PVPK30 was faster than that with PEG-6000. The solid dispersions of sanguis draconis can improve its dissolution obviously, which promotes the absorption and bioavailability of this medicine.