俞丙然 教授


俞丙然

教授,博导,国家自然科学基金优秀青年基金获得者(2021

电话:18610968697

办公室:化新楼B213B
E-mail: yubr@mail.buct.edu.cn

研究领域:

核酸递送高分子载体
药物释放响应材料
功能抗菌材料及机制研究


2010.92013.6 兰州大学     理学博士

2007.92010.6 兰州大学     理学硕士

2002.92006.6 兰州大学     理学学士



2021.1~今     北京化工大学材料科学与工程学院见习教授、教授,博士生导师

2018.12020.12  北京化工大学材料科学与工程学院副教授,硕士生导师

2014.72017.12  北京化工大学材料科学与工程学院讲师


科研情况概述:

国家自然科学基金优秀青年科学基金项目获得者(2021)。主要从事基于开环反应构建功能性阳离子聚合物的制备,并用于癌症、细菌感染等疾病治疗的研究。作为项目负责人,近5年承担国家自然科学基金项目等国家级项目3项。在国内外重要学术期刊发表论文50余篇。


 

近期学术论文

1. Zheng, L.#; Li, J.#; Yu, M.#; Jia, W.; Duan, S.; Cao, D.; Ding, X.; Yu, B.*; Zhang, X.*; Xu, F.J.* Molecular sizes and antibacterial performance relationships of flexible ionic liquid derivatives. Journal of the American Chemical Society. 2020, 142(47): 20257-20269.

2. Wang, J. #; Nie, J.-J. #; Guo, P.; Yan, Z.; Yu, B.*; Bu, W.* Rhodium(I) complex-based polymeric nanomicelles in water exhibiting coexistent near-infrared phosphorescence imaging and anticancer activity in vivo. Journal of the American Chemical Society. 2020, 142(6): 2709-2714.

3. Zhu, Y. #; Wu, S#; Sun, Y.; Zou, X.; Zheng, L.; Duan, S.; Wang, J.; Yu, B.;* Sui, R.;* Xu, F.J.*. Bacteria-targeting photodynamic nanoassemblies for efficient treatment of multidrug-resistant biofilm infected keratitis. Advanced Functional Materials. 2022, 32(8): 2111066.

4. Wu, S.; Xu, C.; Zhu, Y. Zheng, L.; Zhang, L.; Hu, Y.; Yu, B.;* Wang, Y.;* Xu, F.J.*. Biofilm-sensitive photodynamic nanoparticles for enhanced penetration and antibacterial efficiency. Advanced Functional Materials. 2021, 31(33): 2103591.

5. Xu, C.#; Hu, W.#; Zhang, N.; Qi, Y.; Nie, J.-J.; Zhao, N.; Yu, B.*; Xu, F.J.* Genetically multimodal therapy mediated by one polysaccharides-based supramolecular nanosystem. Biomaterials. 2020, 248, 120031.

6. Yu, D.; Zhang, N.; Liu, S.; Hu, W.; Nie, J.-J.; Zhang, K.; Yu, B.*; Wang, Z.-G.*; Xu, F.J.* Self-assembled nucleotide/saccharide-tethering polycation-based nanoparticle for targeted tumor therapy. ACS Materials Letters, 2020, 2(5): 550556.

7. Zhang, N.#; Wang, Y.#; Wu, R.; Xu, C.; Nie, J.J.; Zhao, N.; Yu, B.*; Liu, Z.;* Xu, F.J.* Oxidation-responsive nanoassemblies for light-enhanced gene therapy. Small. 2019, 15(45): 1904017

8. Ye, W.#; Chen, Y.#; Tang, W.; Zhang, N.; Li, Z.; Liu, Z.*; Yu, B.*; Xu, F.J.* Reduction-responsive nucleic acid delivery systems to prevent in-stent restenosis in rabbits. ACS Applied Materials & Interfaces. 2019, 11(31): 28307-28316

9. Zhu, Y; Xu, C.; Zhang, N.; Ding, X.; Yu, B.*; Xu, F.J.*. Polycationic synergistic antibacterial agents with multiple functional components for efficient anti-infective therapy. Advanced Functional Materials. 2018, 28(4): 1706709.

10. Qi, Y.#; Song, H.Q.#; Xiao, H.; Cheng, G.; Yu, B.*; Xu, F.J.* Fluorinated acid-labile branched hydroxyl-rich nanosystems for flexible and robust delivery of plasmids. Small. 2018, 14(42): 1803061.

11. Wu, R.#; Ding, X.K.#; Qi, Y.; Zeng, Q.; Wu, Y.W.; Yu, B.*; Xu, F.J.* Flexible cationic nanoparticles with photosensitizer cores for multifunctional biomedical applications. Small. 2018, 14(22):1800201.

12. Sun, Y.; Hu, H.; Zhao, N.N.; Xia, T.; Yu, B.*; Shen, C.;* Xu, F.J.* Multifunctional polycationic photosensitizer conjugates with rich hydroxyl groups for versatile water-soluble photodynamic therapy nanoplatforms. Biomaterials. 2017, 117: 77-91.

13. Yuan, H.#; Xu, C.#; Zhao, Y.; Yu, B.*; Cheng, G.; Xu, F.J.* Well-defined protein-based supramolecular nanoparticles with excellent MRI abilities for multifunctional delivery systems. Advanced Functional Materials. 2016, 26(17): 2855-2865.

14. Huang, Y.J.#; Ding, X.K.#; Qi, Y.; Yu, B.*; Xu, F.J.*. Reduction-responsive multifunctional hyperbranched polyaminoglycosides with excellent antibacterial activity, biocompatibility and gene transfection capability. Biomaterials. 2016, 106: 134-143.

15. Huang, Y.J.; Hu, H.; Li, R.Q.; Yu, B.*; Xu, F.J.* Versatile types of MRI-visible cationic nanoparticles involving pullulan polysaccharides for multifunctional gene carriers. ACS Applied Materials & Interfaces. 2016, 8(6): 3919-3927.