副教授
办公室:
电话:18101302957
E-mail: yaoqx@nanoctr.cn
研究领域:
1.活体内超分子自组装
2.药物递送与可控释放
2011-09至2017-07,中南林业科技大学,林产化学加工工程,博士
2007-09至2011-07,中南民族大学,材料化学,学士2023-03至今, 北京化工大学, 副教授
2019-08至2023-02,国家纳米科学中心,副研究员
长期致力于超分子功能纳米材料、药物递送及可控释放研究。累积发表研究论文10余篇,包括Nature Communications、Advanced Materials、ACS Nano、Biomaterials等。授权国家发明专利7项。主持国家自然科学基金青年科学基金项目、北京市自然科学基金青年科学基金项目、第12批中国博士后科学基金特别资助、中科院基础前沿科学研究计划等。
1. Jialei Song, Chengling Wu, Yan Zhao, Min Yang, Qingxin Yao,* Yuan Gao*. Bioorthogonal disassembly of tetrazine bearing supramolecular assemblies inside living cells. Small, 2021, 2104772.
2. Qingxin Yao, Shuo Gao, Chengling Wu, Ting Lin*, Yuan Gao*. Enzymatic non-covalent synthesis of supramolecular assemblies as a general platform for bioorthogonal prodrugs activation to combat drug resistance. Biomaterials, 2021, 277, 121119.
3. Qingxin Yao, Chengling Wu, Jiali Chen, Yan Zhao, Yuan Gao*. Enzyme-instructed supramolecular assemblies promote intracellular boron accumulation for boron neutron capture therapy. Nanotechnology, 2021, 32, 435602.
4. Qingxin Yao#, Guangqi Wu#, Hao Hao#, Hua Lu*, Yuan Gao*. Redox-mediated reversible supramolecular assemblies driven by switch and interplay of peptide secondary structures. Biomacromolecules, 2021, 22, 2563-2572.
5. Qingxin Yao#, Chenlei Wang#, Meifang Fu, Luru Dai*, Junbai Li*, and Yuan Gao*. Dynamic detection of active enzyme instructed supramolecular assemblies in situ via super-resolution microscopy. ACS Nano, 2020, 14, 4882-4889.
6. Qingxin Yao, Zhentao Huang, Dongdong Liu, Jiali Chen, Yuan Gao*. Enzyme-instructed supramolecular self-assembly with anticancer activity. Advanced Materials, 2019, 31, 1804814.
7. Qingxin Yao, Feng Lin, Xinyuan Fan, Yanpu Wang, Ye Liu, Zhaofei Liu, Xingyu Jiang, Peng R. Chen*, Yuan Gao*. Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems. Nature Communications, 2018, 9, 5032.
8. Qingxin Yao#, Qiang Bao#, Xinming Li, Hui Wang, Zhenyu Yang, Xinghua Shi*, Yuan Gao*, Bing Xu. Determination of the packing model of a supramolecular nanofiber via mass-per-length measurement and de novo simulation. Nanoscale, 2018, 10, 3990.
1. 高远, 姚庆鑫, 黄振涛, 郝好. 一种具有肿瘤靶向能力的含硼药物及其制备方法和应用. 专利号:ZL201811604254.9
2. 姚庆鑫, 黄振涛, 郝好, 高远. 一种前药激活化合物、前药体系及其制备方法和应用. 专利号:ZL201910218267.0
3. 姚庆鑫, 林锋, 陈鹏, 高远. 一种阿霉素前药及其制备方法和应用. 专利号: ZL202010130441.9
4. 姚庆鑫, 高远. 一种单甲基澳瑞他汀 E 前药及其制备方法和应用. 专利号: ZL202010130608.1
5. 姚庆鑫, 高远. 一种单甲基澳瑞他汀 F 甲酯前药及其制备方法和应用. 专利号: ZL202010131333.3
6. 姚庆鑫, 林挺, 高远. 一种 Mytoxin A 前药及其制备方法和应用. 专利号: ZL202010146545.9
7. 姚庆鑫, 高远. 一种掺硼肿瘤靶向药物及其制备方法和应用. 专利号: ZL202010130473.9