陈博智 见习副教授


陈博智

见习副教授
办公室:化新楼B214
E-mail: chenbz@buct.edu.cn
电话:18810463768  
课题组网站:http://www.microneedlelab.com/

研究领域:

1. 经皮给药及生物诊疗高分子微针

2. 细胞介导的免疫调控靶向系统

3. 生物基可降解材料


2015.9-2021.6  北京化工大学,材料科学与工程,工学博士

2019.9-2020.9  日本大阪大学,应用化学专攻,联合培养博士

2011.9-2015.6  北京化工大学,生物功能材料,工学学士





2023.05-至今    北京化工大学,材料科学与工程学院,副教授

2021.07-2024.04  北京化工大学,材料科学与工程学院,师资博士后、讲师


科研情况概述:

近五年来以第一作者/通讯作者(含共同)在 Science Advances, Advanced Drug Delivery Reviews等期刊发表SCI论文20余篇,申请国家发明专利10余项,以共同作者身份发表论文40余篇,论文总引用1600余次,H指数为24。参与编写中英文著作2部。作为团队负责人获“春晖杯”中国留学人员创新创业大赛优胜奖,连续入围第一届/第二届全国博士后创新创业大赛全国总决赛,中山海外博士博士后创新优胜奖。指导学生获全国大学生生物医学工程创新竞赛二等奖,大学生创新创业训练计划项目(国家级)优秀奖,校级优秀毕业设计(论文)。先后主持国家自然科学基金青年基金,中国博士后科学基金,教育部中央高校自由探索项目、北化-中日重点项目,企业委托项目等多项基金。


 

代表论文

1.Bo Zhi Chen, Li Qin Zhang, Yi Yun Xia, Xiao Peng Zhang, Xin Dong Guo*, A basal-bolus insulin regimen integrated microneedle patch for intraday postprandial glucose control, Science Advances, 2020, 6(28): eaba7260.

2. Bo Zhi Chen, Yu Ting He, Ze Qiang Zhao, Yun Hao Feng, Ling Liang, Juan Peng, Chen Yu Yang, Hiroshi Uyama*, Mohammad-Ali Shahbazi*, Xin Dong Guo*, Strategies to develop polymeric microneedles for controlled drug release. Advanced Drug Delivery Reviews, 2023, 203, 115109.

3. Bo Zhi Chen, Wen Xuan Li, Yun Hao Feng, Xiao Peng Zhang, Jie Jiao, Zhuo Lin Li, Vahideh Nosrati-Siahmazgi, Mohammad-Ali Shahbazi*, Xin Dong Guo*, Functional insulin aspart/insulin degludec-based microneedles for promoting postprandial glycemic control. Acta Biomaterialia, 2023, 171, 350-360.

4. Bo Zhi Chen, Ze Qiang Zhao, Mohammad-Ali Shahbazi*, Xin Dong Guo*, Microneedle-based technology for cell therapy: current status and future directions. Nanoscale Horizons, 2022, 7(7): 715-728.

5. Bo Zhi Chen, Meng Chan He, Xiao Peng Zhang, Wen Min Fei, Yong Cui*, Xin Dong Guo*, A novel method for fabrication of coated microneedles with homogeneous and controllable drug dosage for transdermal drug delivery. Drug Delivery and Translational Research, 2022, 12, 2730-2739.

6. Yuan Yang1, Bo Zhi Chen1, Xiao Peng Zhang, Hui Zheng, Zhou Li*, Can Yang Zhang*, Xin Dong Guo*, Conductive microneedle patch with electricity-triggered drug release performance for atopic dermatitis treatment. ACS Applied Materials & Interfaces, 2022, 14, 31645−31654.

7. Bo Zhi Chen, Jing Ling Liu, Qiu Yu Li, Ze Nan Wang, Xiao Peng Zhang, Chang Bing Shen, Yong Cui, Xin Dong Guo, Safety evaluation of solid polymer microneedles in human volunteers at different application sites. ACS Applied Bio Material, 2019, 2(12): 5616-5625.

8. Bo Zhi Chen, Yuan Yang, Bei Bei Wang, Mohammad Ashfaq, Xin Dong Guo, Self-implanted tiny needles as alternative to traditional parenteral administrations for controlled transdermal drug delivery. International Journal of Pharmaceutics, 2019, 556: 338-348.

9. Bo Zhi Chen, Mohammad Ashfaq, Xiao Peng Zhang, Jia Nan Zhang, Xin Dong Guo, In vitro and in vivo assessment of polymer microneedles for controlled transdermal drug delivery. Journal of Drug Targeting, 2018, 26(8): 720-729.

10. Bo Zhi Chen, Mohammad Ashfaq, Dan Dan Zhu, Xiao Peng Zhang, Xin Dong Guo, Controlled delivery of insulin using rapidly separating microneedles fabricated from genipin-crosslinked gelatin. Macromolecular Rapid Communications, 2018, 39(20): 1800075. (Cover)