尹梅贞 教授

尹梅贞

教授/博导
办公室:科技大厦1017
办公电话:010-64443801
E-mail:yinmz@mail.buct.edu.cn

研究领域:
水溶性荧光染料的细胞/组织标记
自组装分子的生物功能化
功能性核-壳基因载体
双功能有机-无机荧光纳米粒子
有机材料表面的生物功能化
活性/可控自由基聚合

2001-2004年,德国德累斯顿理工大学有机化学系,博士学位,导师:Wolf D. Habicher, Brigitte Voit教授
1996-1999年,北京化工大学材料学院高分子材料,硕士学位,导师:杨万泰教授
1990-1994年,沈阳化工大学高分子系,学士学位,导师:崔连复教授

2010 至今,北京化工大学材料学院,教授, 博士生导师
2009 至今,北京化工大学材料学院,教授
2005-2008年,德国高分子马普所,美因茨,博士后,导师:************教授
1999-2000年,北京化工研究院聚烯烃中心,工程师
1994-1996年,北京第四制药厂质检科,助理工程师


研究成果及获奖情况:

  尹梅贞教授长期从事荧光纳米材料的构建与生物学应用研究,发明了多种特异性荧光分子探针以及新型荧光抗癌药物分子。她的研究工作具有前瞻性,引领了纳米材料与农业及生物医学的交叉,带动了荧光标记以及抗肿瘤研究领域的发展,开创性地建立了纳米材料载体应用于农业害虫防治的新技术平台,有助于避免化学农药的过度使用,实际应用前景广阔。以第一/通讯作者在国际学术期刊(如Nature Commun, J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mater., Chem. Soc. Rev., Acc. Chem. Res., Prog. Poly. Sci., Adv. Funct. Mater., Chem. Mater., ACS Nano, Chem. Sci., Small, ACS AMI, Nanoscale, Chem. Comm.等)发表相关SCI学术论文100余篇, 申请专利30项,授权21项。

  2019年,北京化工大学“重大科技进展”2018年,北京市“三八红旗奖章”称号 2017年,第三批“万人计划”科技创新领军人才 2017年,第九届侯德榜化工科技奖(创新奖) 2017年,北京市高校优秀共产党员 2016年,第十三届“中国青年女科学家奖” 2016年,科技部“中青年科技创新领军人才” 2016年,北京化工大学“校长奖” 2016年,“心血管重大疾病2011协同创新中心”聘任专家 2014年,北京化工大学优秀共产党员 2013年,“高层次引进人才”结题答辩“优秀” 2010年,教育部“新世纪优秀人才” 2005年,Max Planck Researcher Fellowship, Germany 2000年,Technical University of Dresden, Doctoral Fellowship, Germany


代表性研究论文:  

1. C. Ji, W. Cheng, Q. Yuan, K. Müllen, M. Yin*, From Dyestuff Chemistry to Cancer Theranostics: The Rise of Rylenecarboximides, Acc. Chem. Res. 2019, 52, 2266-2277. (IF: 21.661, TOP)  

2. B. Lü, Y. Chen, P. Li, B. Wang, K. Müllen, M. Yin*, Stable radical anions generated from a porous perylenediimide metal-organic framework for boosting near-infrared photothermal conversion, Nat. Commun. 2019, 10, 767-774. (IF: 11.878, TOP)

3. Zh. Wu, C. Ji, X. Zhao, Y. Han, K. Müllen, K. Pan, M. Yin*, Green-Light-Triggered Phase Transition of Azobenzene Derivatives toward Reversible Adhesives, J. Am. Chem. Soc. 2019, 141, 7385-7390. (IF: 14.695, TOP)

4. C. Liu, S. Zhang, J. Li, J. Wei, K. Müllen, M. Yin*, A Water-Soluble, NIR-Absorbing Quaterrylenediimide Chromophore for Photoacoustic Imaging and Efficient Photothermal Cancer Therapy, Angew. Chem. Int. Ed. 2019, 58, 1638-1642. (IF: 12.257, TOP)

5. C. Ji, Q. Gao, X. Dong, W. Yin,* Z. Gu, Z. Gan, Y. Zhao, Meizhen Yin*, A Size-Reducible Nanodrug with an Aggregation-Enhanced Photodynamic Effect for Deep Chemo-Photodynamic Therapy, Angew. Chem. Int. Ed. 2018, 57, 11384-11388.

6. Z. Wu, S. Mo, L. Tan, B. Fang, Z. Su, Y. Zhang,M. Yin*, Crystallization-Induced Emission Enhancement ofa Deep-Blue Luminescence Material with TunableMechano- and Thermochromism, 10.856, TOP)

7. S. Mo, Q. Meng, S. Wan, Z. Su, H. Yan, B. Z. Tang*, M. Yin*, Tunable Mechanoresponsive Self-Assembly of an Amide-Linked Dyad with Dual Sensitivity of Photochromism and Mechanochromism, Adv. Funct. Mater. 2017, 27, 1701210.

8. S. Zhang, W. Guo, J. Wei, C. Li, X. Liang*, M. Yin*, Terrylenediimide-Based Intrinsic Theranostic Nanomedicines with High Photothermal Conversion Efficiency for Photoacoustic Imaging-Guided Cancer Therapy, ACS Nano 2017, 11, 3797-3805.

9. W. Cheng, H. Cheng, S. Wan, X. Zhang*, M. Yin*, Dual-stimuli-responsive Fluorescent Supramolecular Prodrug for Antitumor Drug Delivery, Chem. Mater. 2017, 29, 4218-4226.

10. M. Sun, K. Müllen, M. Yin*, Water-soluble perylenediimides: design concepts and biological applications, Chem. Soc. Rev. 2016, 45, 1513-1528.

11. Y. Zheng, S. You, C. Ji, M. Yin*, W. Yang, J. Shen*, Development of an Amino Acid-Functionalized Fluorescent Nanocarrier to Deliver a Toxin to Kill Insect Pests, Adv. Mater. 2016, 28, 1375-1380.

12. S. Wan, Z. Ma, C. Chen, F. Li, F. Wang, X. Jia, W. Yang, M. Yin*, A Supramolecule-Triggered Mechanochromic Switch of Cyclodextrin-jacketed Rhodamine and Spiropyran Derivatives, Adv. Funct. Mater. 2016, 26, 353-364.

13. K. Liu, Z. Xu, M. Yin*, Perylenediimide-Cored Dendrimers and Their Bioimaging and Gene Delivery Applications, Prog. Polym. Sci. 2015, 46, 25-54.

14. M. Chen, M. Yin*, Design and Development of Fluorescent Nanostructures for Bioimaging, Prog. Polym. Sci. 2014, 39, 365-395.

15. B. He, Y. Chu, M. Yin*, K. Müllen, C. An*, J. Shen*, Fluorescent Nanoparticle Delivered dsRNA toward Genetic Control of Insect Pest, Adv. Mater. 2013, 25, 4580-4584. (IF="25.809," TOP)

16. M. Yin*, J. Shen, W. Pisula, M. Liang, L. Zhi, K. Müllen*, Functionalization of Self-Assembled Hexa-peri-hexabenzocoronene Fibers with Peptides for Bioprobing, J. Am. Chem. Soc. 2009, 131, 14618-14619. (IF: 14.695, TOP)

17. M. Yin, Y. Cheng, M. Liu, J. S. Gutmann, K. Müllen*, Nanostructured Ultrathin Anatase TiO2 Films Templated by Amphiphilic Core-Shell Nanoparticle, Angew. Chem. 2008, 120, 8528-8531, Angew. Chem. Int. Ed. 2008, 47, 8400-8403. (IF: 12.257, TOP)

18. M. Yin, J. Shen*, G. O. Pflugfelder, K. Müllen*, A Fluorescent Core-shell Dendritic Macromolecule Specifically Stains the Extracellular Matrix, J. Am. Chem. Soc. 2008, 130, 7806-7807. (IF: 14.695, TOP)