高远 教授


高远

教授/博士生导师,国家自然科学基金优秀青年基金获得者(2021)
  办公室:n.a.
  电   话:n.a.
  E-mail: cmse.gaoy@buct.edu.cn
  课题组网站:https://www.x-mol.com/groups/gao-lab
  研究领域:
  1.活体内超分子组装方法学
  2.超分子组装体的动态变构
  3.药物递送与生物正交前药
  4.动态光散射小角中子散射


2008.09-2011.07      美国布兰戴斯大学,博士

2005.09-2008.08      香港科技大学

2001.09-2005.06      南京大学,学士



2023.03 - 至 今      北京化工大学,材料科学与工程学院    教授,博士生导师

2015.11-2023.02   国家纳米科学中心   研究员,博士生导师

2013.03-2015.03   美国国立卫生研究院   博士后

2011.10-2013.02   美国布兰戴斯大学化学系   博士后

科研情况概述:

从事超分子自组装及生物纳米材料方向的研究。发表论文60余篇,包括Sci.Adv.Nat. Commun.Adv. Mater.JACS.Chem. Soc. Rev.等,引用5500余次。已授权9项中国专利,1项美国专利。获NRC RAP Award,主持中科院“率先行动”百人计划(择优支持),国家重点研发计划课题,基金委面上、优秀青年基金等项目。


 

代表论文

1Chen, J.#, Zhang, P.#, Zhao, Y., Zhao, J., Wu, X., Zhang, R., Cha, R., Yao, Q., Gao, Y.* “Nitroreductase-Instructed Supramolecular Assemblies for Microbiome Regulation to Enhance Colorectal Cancer Treatments” Sci. Adv. 2022, 8, eadd2789.

2.  Tian, F.#, Yang, M.#, Yao, Q., Song, J., He, J., Shi, X.*, Gao, Y.* “Kinetic Selectivity Dictates the Construction of Cancer Cell-Targeting Enzyme Instructed Supramolecular Assemblies” Nano Today, 2022, 47, 101658.

3.  Yao, Q., Gao, S., Wu, C., Lin, T.*, Gao, Y.* “Enzymatic non-covalent synthesis of supramolecular assemblies as a general platform for bioorthogonal prodrugs activation to combat drug resistance” Biomaterials, 2021, 277, 121119.

4.  Huang, Z.#, Liu, Y.#, Wang, L., Ali, A., Yao, Q., Jiang, X.*, Gao, Y.* “Supramolecular Assemblies mimicking Neutrophil Extracellular Traps for MRSE Infection Control” Biomaterials, 2020, 253, 120124.

5.  Yao, Q.#, Wang, C.#, Fu, M., Dai, L.*, Li, J.*, Gao, Y.* “Dynamic Detection of Active Enzyme Instructed Supramolecular Assemblies In Situ via Super-Resolution Microscopy” ACS Nano, 2020, 14, 4882-4889.

6.  Yao, Q., Huang, Z., Liu, D., Chen, J., Gao, Y.* “Enzyme-Instructed Supramolecular Self-Assembly with Anticancer Activity” Adv. Mater., 2019, 31, 1804814.

7.  Yao, Q., Lin, F., Fan, X., Wang, Y., Liu, Y., Liu, Z., Jiang, X., Chen, P.*, Gao, Y.* “Synergistic Enzymatic and Bioorthogonal Reactions for Selective Prodrug Activation in Living Systems” Nat. Commun., 2018, 9, 5032.

8.  Huang, P.*, Gao, Y.*, Lin, J., Hu, H., Liao, H., Yan, X., Tang, Y., Jin, A., Song, J., Niu, G., Zhang, G., Horkay, F., Chen, X.* “Tumor-Specific Formation of Enzyme-Instructed Supramolecular Self-Assemblies as Cancer Theranostics” ACS Nano, 2015, 9, 9517–9527

9.  Gao, Y.; Shi, J. F.; Yuan, D.; Xu, B.* “Imaging enzyme-triggered self-assembly of small molecules inside live cells” Nat. Commun., 2012, 3, 1033.

10. Gao, Y.; Kuang, Y.; Guo, Z.-F.; Guo, Z. H.; Krauss, I. J.; Xu, B.* “Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and A Supramolecular Hydrogel of Taxol Derivative” J. Am. Chem. Soc., 2009, 131, 13576-13577.